Daniel Roderer

Atomic structure and plasticity of the MthK-CTX complex investigated by cryo-EM, NMR, and MD simulations

The paper investigates the binding of scorpion toxin CTX to the MthK channel using cryo-EM, NMR, and MD simulations to explain toxin affinity and subtype tolerance.

Atomic structure and dynamics of the mechanosensitive channel MscL from E. coli by cryo-EM and solid-state NMR

This study uses cryo-EM and solid-state NMR to determine the structure and dynamics of MscL from E. coli, revealing lipid-protein interactions that drive mechanosensitive gating.

Characterization of the direct and indirect inhibition ofapoptosis by full-length recombinant Bcl-xL monomers

This study characterizes how full-length recombinant Bcl-xL monomers inhibit apoptosis through direct and indirect mechanisms using in vitro and organelle assays.

Structural basis of Fusobacterium nucleatum adhesin Fap2 interaction with receptors on cancer and immune cells

This study determines the structural basis of Fusobacterium nucleatum adhesin Fap2 interactions with Gal-GalNAc and TIGIT, revealing binding mechanisms and structural details.

Nucleoside diphosphate kinase A (NME1) catalyze its own oligophosphorylation

This study identifies oligophosphorylation as a new phosphorylation mode, showing NME1 can catalyze its own oligophosphorylation using ATP, with implications for phosphoregulation.

Structural basis for immune cell binding of Fusobacterium nucleatum via the trimeric autotransporter adhesin CbpF

This study presents the first structural description of the fusobacterial TAA CbpF and its interaction with CEACAM1, revealing a novel binding mode and potential targets for drug design in CRC.

C. perfringens enterotoxin-claudin pore complex: Models for structure, mechanism of pore assembly and cation permeability

The paper models the structure and mechanism of the CPE-claudin-4 pore complex, revealing its hexameric architecture and cation selectivity.

Glycan-dependent two-step cell adhesion mechanism of Tc toxins

This study identifies two glycans, heparins/heparan sulfates and Lewis antigens, as receptors for Tc toxins, revealing a two-step adhesion mechanism involving glycan binding to toxin subunits.

Structure of a Tc holotoxin pore provides insights into the translocation mechanism

The paper determines the structure of a Tc holotoxin pore and elucidates its translocation mechanism through conformational changes and lipid interactions.

Conserved architecture of Tc toxins from human and insect pathogenic bacteria

The paper presents high-resolution structures of five TcA toxins from different bacteria, revealing conserved architecture and a common mechanism of action despite previous suggestions of variability.