Activation mechanism of class A GPCRs: machine learninganalysis of experimental structural databases
Santeri Elias Paajanen, Felix Eurasto, Waldemar Kulig, Ksenia Korshunova, Shreyas Kaptan, Ilpo Vattulainen
This study uses machine learning to analyze structural data of class A GPCRs, revealing that ligand binding follows conformational selection while G protein binding stabilizes the active state.
bioRxiv · Mar 27, 2026 · PreprintBiophysics