Ilpo Vattulainen

This study shows that TNS1 phase separation regulates adhesion dynamics by controlling the availability of inactive adhesion proteins through phosphorylation-dependent condensate formation.

This study identifies an oncogenic TMD mutation in IL-7R that causes ligand-independent signaling and shows that rationally designed transmembrane helices can reverse this effect.

This study uses machine learning to analyze structural data of class A GPCRs, revealing that ligand binding follows conformational selection while G protein binding stabilizes the active state.

This study identifies Adig as a regulator of lipid droplet formation by stabilizing the dodecameric seipin complex, leading to increased fat mass and thermogenesis in mice.

This study shows that Sac1 regulates Golgi V-ATPase assembly by controlling TGN membrane composition through lipid exchange, leading to Golgi fragmentation and impaired glycosylation.

The paper introduces an open-source tool for classifying containment in periodic point clouds, demonstrating its effectiveness on both coarse-grained and atomistic systems.

This study investigates Galectin-1's specificity for GM1 over GD1a in lipid membranes and finds no evidence of cross-linking by homodimers.

The paper identifies CRAC and CARC motifs in RTK transmembrane domains, showing cholesterol interaction with TRKB's CARC motif and its effect on BDNF binding.

This study identifies a direct binding of antidepressants to TRKB receptors, revealing a mechanism linking molecular interactions to antidepressant effects.

This study shows how N-glycosylation modulates CD44's binding to hyaluronan by altering binding site affinity and promoting weaker interactions.