BiophysicsbioRxivPreprint
Activation mechanism of class A GPCRs: machine learninganalysis of experimental structural databases
Santeri Elias Paajanen, Felix Eurasto, Waldemar Kulig…·Ilpo Vattulainen
This study uses machine learning to analyze structural data of class A GPCRs, revealing that ligand binding follows conformational selection while G protein binding stabilizes the active state.
DOI 10.64898/2026.03.26.714415