Hypoxia-mediated fine-tuning of the TLR7/9-triggered human PDC-derived IFN-α response is mediated by combined cellular and soluble IFN-regulators
Alexander Lenkewitz, Ibtissem Ben Brahim, Felix Herrmann, Noor-A-Kasida Islam, Olga Tichá, Isabelle Bekeredjian‐Ding
The paper shows hypoxia reduces IFN-α secretion from PDCs but preserves their production capacity, mediated by soluble factors and cell contact mechanisms.
bioRxiv · Sep 15, 2024 · PreprintImmunology