Morphologic intratumoral heterogeneity from routine whole-slide histopathology is prognostic for survival in primary central nervous system lymphoma: development in the LOC Network and international external validation
Lucas Rincón de la Rosa, Noemie Barillot, Isaias Hernández-Verdín, Roser Velasco, Bertrand Mathon, Sandrine Eimer, Jean Rodolphe Vignes, Audrey Rousseau, Jérôme Paillassa, Guido Ahle, Felix Lerintiu, Emmanuelle Uro‐Coste, Lucie Obéric, Émeline Tabouret, Romain Appay, , Agustí Alentorn
The paper develops and validates a prognostic model using morphologic intratumoral heterogeneity from histopathology slides to predict survival in primary central nervous system lymphoma.
bioRxiv · Sep 3, 2026 · PreprintBioinformatics