Bertrand Mathon

Morphologic intratumoral heterogeneity from routine whole-slide histopathology is prognostic for survival in primary central nervous system lymphoma: development in the LOC Network and international external validation

The paper develops and validates a prognostic model using morphologic intratumoral heterogeneity from histopathology slides to predict survival in primary central nervous system lymphoma.

Enhancing KCC2 function reduces interictal activity and prevents seizures in mesial temporal lobe epilepsy

This study identifies two compounds that enhance KCC2 function, reducing interictal activity and preventing seizures in mesial temporal lobe epilepsy.

Activating Ras-MAPK pathway variants drive hippocampal clonal competition in human epilepsy

This study identifies somatic Ras-MAPK pathway variants in hippocampal tissue from patients with drug-resistant epilepsy, showing their association with clonal competition and worse surgical outcomes.

Oncometabolite-driven enhancer hypermethylation promotes a hyporesponsive microglial state in IDH-mutant gliomas

This study shows that oncometabolite D-2HG drives enhancer hypermethylation in IDH-mutant gliomas, leading to hyporesponsive microglia and reduced immune reactivity.

Sleep increases firing rate modulation during interictal epileptic activities in mesial structures

This study examines how sleep stages affect neuronal firing rates during interictal epileptic activities in mesial temporal structures, finding increased firing rate modulation in deeper NREM sleep.

Anterior thalamic excitation and feed-forward inhibition of presubicular neurons projecting to medial entorhinal cortex

The paper investigates how thalamic inputs shape presubicular microcircuits in mice, revealing distinct synaptic dynamics that modulate head direction signals before they are transmitted to the medial entorhinal cortex.

How activity dependent feedback inhibition may maintain head direction signals in mouse presubiculum

The paper investigates how feedback inhibition from Martinotti interneurons maintains head direction signals in the mouse presubiculum through synaptic interactions and network dynamics.