Tryptophan-substitution antimicrobial peptide temporin-1CEb: in vitro and in vivo antibacterial activity against clinically isolated multidrug-resistant Klebsiella pneumoniae
Fengquan Jiang, Yanjun Ma, Yunfei Zhang, Dejing Shang, Weibing Dong
This study evaluates Trp-substituted antimicrobial peptides against multidrug-resistant K. pneumoniae, finding that I1WL5W shows superior antibacterial activity, reduced cytotoxicity, and effective biofilm disruption and therapeutic efficacy in a murine model.
bioRxiv · Dec 30, 2025 · PreprintPharmacology & Toxicology