A Generative Foundation Model for Cryo-EM Densities
Yilai Li, Jing Yuan, Yi Zhou, Zhenghua Wang, S. C. Chen, Fengyu Yang, Haibin Ling, Shahar Z. Kovalsky, Xiaoqing Zheng, Quanquan Gu
This paper introduces cryoFM, a generative foundation model for cryo-EM densities that improves reconstruction and refinement by combining data-driven priors with dataset-specific constraints.
bioRxiv · Dec 29, 2025 · PreprintBiophysics