Mitochondrial diabetes in mice expressing a dominant-negative allele of nuclear respiratory factor-1 (NRF1) in pancreatic and β-cells
Fionnuala M. Morrish, Hélène Gingras, Joanna Noonan, Li Huang, Ian R. Sweet, Iok Teng Kuok, Sue E. Knoblaugh, David M. Hockenbery
This study generates mice with reduced NRF1 function in β-cells, showing impaired β-cell function and mitochondrial defects leading to diabetes.
Biochemical and Biophysical Research Communications · Dec 1, 2024Peer-reviewedMolecular Biology