Intratumoral delivery of FLT3L with CXCR3/CCR5 ligands promotes XCR1+ cDC1 infiltration and activates anti-tumor immunity
Louise Gorline, Fillipe Luiz Rosa Do Carmo, Pierre Bourdely, Jérémie Bornères, Nathan Vaudiau, Aurélie Semervil, Mathias Vétillard, Aboubacar Sidiki K. Coulibaly, Natacha Jugniot, Agathe Ok, Mathilde Bausart, Oriane Fiquet, Marine Andrade, Dicken Fardol, Ikrame Haddar, , Pierre Guermonprez
The paper demonstrates that delivering FLT3L with CXCL9 and CCL5 enhances cDC1 infiltration and antitumor immunity in mice and humanized models.
Nature Communications · Dec 30, 2025Peer-reviewedImmunology