Pierre Guermonprez

This study shows that T cell engagers induce endogenous vaccination by triggering a cytotoxic wave and cross-priming of CD8 T cells via dendritic cells.

The paper demonstrates that delivering FLT3L with CXCL9 and CCL5 enhances cDC1 infiltration and antitumor immunity in mice and humanized models.

This study identifies Rab32 as essential for cDC1-mediated cross-priming of CD8 T cells against cell-associated antigens in vivo, but not ex vivo.

The paper shows that DC-based therapy enhances CD8 T cell responses to neoantigens in lung tumors, particularly in high TMB tumors.