Layer-by-Layer Polymeric Films: A Novel Approach to Buccal GLP-1 Delivery
Eleftheria Pantazoglou, Floriane Bahuon, Amalie Kjær Andresen, Matteo Tollemeto, Zhongyang Zhang, Ioannis Tzitzigiannis, Nazanin Zanjanizadeh Ezazi, Margarida M. A. Sacramento, João Filipe Mano, Gavrielle Rebecca Untracht, Peter E. Andersen, Marco van de Weert, Ragna Berthelsen, Stephen Timothy Buckley, Leticia Hosta‐Rigau, , Line Hagner Nielsen
This paper develops multilayer polymeric films for buccal delivery of GLP-1-RA and GDC, showing that triple-layer films provide sustained release and better mucosal compatibility than dual-layer films.
bioRxiv · Jan 22, 2026 · PreprintBioengineering