Developmental switch dichotomizes kidney response to NPHP3 inactivation and treatment outcome
Joran Martin, Alice S. Serafin, Florine Chereau, Younès Achouri, Nicolas Cagnard, Marie‐Christine Verpont, Alexandre Benmerah, Isabelle Scheers, Patrick Jacquemin, Sophie Saunier, Amandine Viau
This study generates two mouse models of nephronophthisis by inactivating Nphp3 at different developmental stages, revealing distinct disease mechanisms and treatment responses.
bioRxiv · May 26, 2026 · PreprintPathology