Younès Achouri

This study identifies HNF1B and NPHP3 mutations as causes of a new pancreatic disease, ciliogenic pancreatopathy, characterized by acinar atrophy and adipose replacement, and links ciliary dysfunction to pancreatic dysfunction in humans and mice.

This study generates two mouse models of nephronophthisis by inactivating Nphp3 at different developmental stages, revealing distinct disease mechanisms and treatment responses.

This study identifies skNAC as critical for maintaining cardiomyocyte integrity and preventing heart failure by regulating proteome homeostasis and metabolic adaptation during pathological hypertrophy.

This study investigates the cooperative role of Emx2 and Dmrta2 in cortex development and reveals distinct functions of Dmrta2 in choroid plexus formation.

This study identifies m3C as a novel mitochondrial mRNA modification catalyzed by METTL8, which promotes tumor progression by enhancing complex I activity and oncogenic pathways.

This study shows Dmrta2 represses Pax6 in cortical progenitors and identifies a DNA-binding mutation linked to microcephaly in humans.

The paper shows that Dach1's temporal refinement is essential for the transcriptional maturation of somatosensory neurons.