The ratio of RUNX1-ETO oncoprotein to normal RUNX1 expression determines the balance between endothelial reprogramming and hematopoietic cell growth
Floyd Hassenrueck, Katerina Terolli, Alexander Maytum, Peter Keane, Léa Flippe, Sophie G. Kellaway, Edouard G. Stanley, Elizabeth Ng, Andrew G. Elefanty, Constanze Bonifer
The study shows that RUNX1-ETO levels determine endothelial reprogramming and hematopoietic cell growth in AML by altering the balance between these processes.
bioRxiv · Dec 23, 2025 · PreprintCancer Biology