This paper benchmarks spatial transcriptomics in stem cell-derived organoids using Stereo-seq, optimizing RNA capture and introducing regional analysis methods.

iScience · Apr 21, 2026Peer-reviewedBioinformatics

The ratio of RUNX1-ETO oncoprotein to normal RUNX1 expression determines the balance between endothelial reprogramming and hematopoietic cell growth

Floyd Hassenrueck, Katerina Terolli, Alexander Maytum, Peter Keane, Léa Flippe, Sophie G. Kellaway, Edouard G. Stanley, Elizabeth Ng, Andrew G. Elefanty, Constanze Bonifer

The study shows that RUNX1-ETO levels determine endothelial reprogramming and hematopoietic cell growth in AML by altering the balance between these processes.

bioRxiv · Dec 23, 2025 · PreprintCancer Biology

Macrophages Mediate Antiviral Immunity and Repair of Type 2 Alveolar Epithelial Cells in a Human Stem Cell Model

Declan L. Turner, Hannah Baric, Katelyn Patatsos, Sahel Amoozadeh, Michael See, Kathleen A. Strumila, Jack T. Murphy, Liam Gubbels, Elizabeth Ng, Andrew G. Elefanty, Melanie R. Neeland, Shivanthan Shanthikumar, Sarah L. Londrigan, Mirana Ramialison, Fernando Jaime Rossello, , Rhiannon B. Werder

This study develops an iPSC-derived air-liquid interface platform to study AT2-macrophage interactions in homeostasis, infection, and repair, revealing their roles in antiviral immunity and epithelial repair.

bioRxiv · Apr 15, 2025 · PreprintCell Biology