Systematic benchmarking of basecalling models for RNA modification detection with highly multiplexed nanopore sequencing
Gregor Diensthuber, Ivan Milenkovic, Laia Llovera, Ana Milovanovic, Francesco Pelizzari, Eva Maria Novoa
This study benchmarks RNA modification detection models using synthetic and biological data, finding high reliability but issues with false positives and cross-reactivity.
Nucleic Acids Research · Apr 7, 2026Peer-reviewedBioinformatics