Laia Llovera

Single-molecule m6A profiling reveals position-dependent mRNA regulation and non-canonical roles for Ythdf2 in early embryogenesis

The paper uses single-molecule m6A profiling to study mRNA regulation during zebrafish MZT, finding m6A's role in mRNA decay and poly(A) tail dynamics.

AMaNITA: an end-to-end workflow for native tRNA nanopore sequencing data analysis

AMaNITA provides an end-to-end workflow for analyzing nanopore native tRNA sequencing data, enabling differential abundance and modification stoichiometry analysis.

Host tRNA modifications drive efficient translation of influenza A virus genome and impact host antiviral stress responses

The paper shows that host tRNA modifications are critical for efficient influenza A virus translation and antiviral responses, with ELP3 loss impairing viral propagation.

Systematic benchmarking of basecalling models for RNA modification detection with highly multiplexed nanopore sequencing

This study benchmarks RNA modification detection models using synthetic and biological data, finding high reliability but issues with false positives and cross-reactivity.

Selective profiling of translationally active tRNAs and their dynamics under stress

The paper introduces tRIBO-seq, a nanopore-based method to profile ribosome-associated tRNAs, revealing stress-induced changes in tRNA abundance, modification, and fragmentation.

SeqTagger, a rapid and accurate tool to demultiplex direct RNA nanopore sequencing datasets

SeqTagger demultiplexes direct RNA nanopore sequencing datasets with high precision and recall, supporting multiple chemistries and library types.

De novo basecalling of m6A modifications at single molecule and single nucleotide resolution

This paper introduces m6ABasecaller, a method for de novo basecalling of m6A modifications at single molecule and single nucleotide resolution using nanopore sequencing.

Epitranscriptomic rRNA fingerprinting reveals tissue-of-origin and tumor-specific signatures

The paper uses rRNA modification patterns to identify tissue and tumor-specific signatures, showing their potential as diagnostic biomarkers.

Enhanced detection of RNA modifications and mappability with high-accuracy nanopore RNA basecalling models

This paper shows that using high-accuracy nanopore RNA basecalling models improves detection of RNA modifications, read mappability, and basecalling accuracy.

Y chromosome sequence and epigenomic reconstruction across human populations

The paper uses long-read sequencing to generate and compare Y chromosome assemblies across haplogroups and assesses epigenetic modifications in human populations.