Mechanistic Link Between Glyoxalase 1 Expression and Methylglyoxal-Induced Oncogenic Stress in Prostate Cancer
Alana Battad, Francisco Nunez, Mya Walker, Sydney Hodge, Kelani Sun, Elise Desjarlais, Edwin DJ Lopez Gonzalez, Seigmund Wai Tsuen Lai, Leanne Woods‐Burnham, Stanley E. Hooker, Rayyan Aburajab, Qianhua Feng, Min Talley, Sharon Baumel-Alterzon, David Wesley Craig, , Sarah C. Shuck
This study links elevated methylglyoxal-adducts and GLO1 genetic variants in African American/Black men with prostate cancer progression through metabolic reprogramming and impaired detoxification.
bioRxiv · Dec 9, 2025 · PreprintCancer Biology