Author

John S. Termini

City Of Hope National Medical CenterORCID 0000-0002-4043-7552Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

Alana Battad· 1 shared Cole DolamoreiD· 1 shared David Wesley CraigiD· 1 shared Doeke R. HekstraiD· 1 shared Edwin DJ Lopez Gonzalez· 1 shared Elise Desjarlais· 1 shared Francisco Nunez· 1 shared Kara A. ZielinskiiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

Alana Battad

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Mechanistic Link Between Glyoxalase 1 Expression and Methylglyoxal-Induced Oncogenic Stress in Prostate Cancer

Alana Battad, Francisco Nunez, Mya Walker, Sydney Hodge, Kelani Sun, Elise Desjarlais, Edwin DJ Lopez Gonzalez, Seigmund Wai Tsuen Lai, Leanne Woods‐Burnham, Stanley E. Hooker, Rayyan Aburajab, Qianhua Feng, Min Talley, Sharon Baumel-Alterzon, David Wesley Craig, , Sarah C. Shuck

This study links elevated methylglyoxal-adducts and GLO1 genetic variants in African American/Black men with prostate cancer progression through metabolic reprogramming and impaired detoxification.

bioRxiv · Dec 9, 2025 · PreprintCancer Biology

Resolving DJ-1 Glyoxalase Catalysis Using Mix-and-Inject Serial Crystallography at a Synchrotron

Kara A. Zielinski, Cole Dolamore, Kevin M. Dalton, Nathan Smith, John S. Termini, Robert William Henning, V. Šrajer, Doeke R. Hekstra, Lois Pollack, Mark A. Wilson

This study uses mix-and-inject serial crystallography to resolve the catalytic mechanism of DJ-1, showing it catalyzes nearly two turnovers and reveals allosteric communication during glyoxalase activity.

bioRxiv · Jul 19, 2024 · PreprintBiochemistry