Identification of Injury-Response State Determinants in Glioblastoma Stem Cells
Fatemeh Molaei, Graham Dickson and Hugh MacLeod, Shahan Haider, Aleczandria S. Tiffany, Frank M Oteng, Jacob M. Berman, Arianna Skirzynska, Molly Sandra Shoichet, Daniel Schramek, Peter B. Dirks, Stéphane Angers
This study identifies EP300 as a regulator of the Injury-Response state in Glioblastoma Stem Cells through a CRISPR-Cas9 screen, showing its role in maintaining IR state features and tumor aggressiveness.
bioRxiv · Apr 7, 2025 · PreprintCancer Biology