Daniel Schramek

Ependymomas are cancers of the pre-neural crest/roof plate lineage

The paper identifies ependymomas as originating from the pre-neural crest/roof plate lineage using single-cell transcriptomics and lineage tracing.

Systematic Discovery of Pathogen Effector Functions across Human Pathogens and Pathways

The paper systematically identifies effector functions of pathogen ORFs across multiple pathways, revealing new roles for known effectors and uncharacterized proteins.

Temporal control of sgRNA library activation unlocks large-scale in vivo CRISPR screens

This paper introduces CRISPR-StAR, an in vivo CRISPR screening platform with improved normalization and analysis tools, showing it can identify tumor suppressor gene effects not observable in vitro.

Topoisomerase IIb binding underlies frequently mutated elements in cancer genomes

The paper identifies TOP2B binding sites as mutational hotspots in cancer genomes, showing their role in structural variants and driver mutations in genes like TP53 and MYC.

De novo design of potent inhibitors of Clostridioides difficile toxin B

This paper designs potent small protein inhibitors of C. difficile toxin B using deep learning and Rosetta, showing high affinity and stability for potential clinical use.

Coupling between acid-sensing ion channel 1a and the monocarboxylate transporter family shapes cellular pH response

The paper identifies a functional interaction between ASIC1a and MCT1 that modulates proton sensitivity and desensitization, showing its role in glioblastoma cell survival and mouse lifespan.

Identification of Injury-Response State Determinants in Glioblastoma Stem Cells

This study identifies EP300 as a regulator of the Injury-Response state in Glioblastoma Stem Cells through a CRISPR-Cas9 screen, showing its role in maintaining IR state features and tumor aggressiveness.

De novo designed inhibitor confers protection against lethal toxic shock

The paper designs a potent inhibitor against P. sordellii lethal toxin using deep learning, showing protective effects in mice against toxic shock.

Identification of the C. sordellii lethal toxin receptor elucidates principles of receptor specificity in clostridial toxins

The paper identifies SEMA6A and SEMA6B as receptors for C. sordellii lethal toxin and shows how mutations can switch receptor specificity between related toxins.