Screening for pro-adhesive compounds and their relevance as therapeutic approach in Arrhythmogenic Cardiomyopathy
Pauline Hanns, Robin M. W. Colpaert, Ramón Castellanos-Martínez, Frauke Weidner, Stefanie Beensen, Franziska Matthias, Lifen Xu, Gabriela M. Kuster, Camilla Schinner
This study identifies pro-adhesive compounds from an FDA-approved drug library that restore cell-cell adhesion in ACM patient mutations and show protective effects in a mouse model.
bioRxiv · Mar 23, 2025 · PreprintPathology