Penetrance and Pleiotropy of Polygenic Risk Scores for Schizophrenia, Bipolar Disorder, and Depression in the VA Health Care System
Tim B. Bigdeli, Georgios Voloudakis, Peter B. Barr, Bryan R. Gorman, Giulio Genovese, Roseann Elizabeth Peterson, David Burstein, Vlad I. Velicu, Yuli Li, Rishab Gupta, Manuel Mattheisen, Simone Tomasi, Nallakkandi Rajeevan, Frederick G. Sayward, Krishnan Radhakrishnan, , Panos Roussos
The paper validates polygenic risk scores for schizophrenia, bipolar disorder, and depression using VA EHR data and shows their association with disease risk and hospitalization.
medRxiv · Feb 16, 2022 · PreprintGenetic & Genomic Medicine