Krishnan Radhakrishnan

Penetrance and Pleiotropy of Polygenic Risk Scores for Schizophrenia, Bipolar Disorder, and Depression in the VA Health Care System

The paper validates polygenic risk scores for schizophrenia, bipolar disorder, and depression using VA EHR data and shows their association with disease risk and hospitalization.

GWAS of Depression Phenotypes in the Million Veteran Program and Meta-analysis in More than 1.2 Million Participants Yields 178 Independent Risk Loci

This study identifies 178 independent risk loci for depression through a large meta-analysis across multiple cohorts, including fine-mapping and transcriptome-wide association findings.

Reproducible Risk Loci and Psychiatric Comorbidities in Anxiety: Results from ~200,000 Million Veteran Program Participants

This paper conducts GWAS on anxiety traits in the Million Veteran Program, identifying significant genetic loci and demonstrating genetic overlap with depression.

Genomic Characterization of Posttraumatic Stress Disorder in a Large US Military Veteran Sample

This study identifies genetic loci associated with PTSD and its symptoms using a large veteran cohort, showing high genetic correlations between symptom sub-domains and potential drug targets.