Synovial Sarcoma Chromatin Dynamics Reveal a Continuum in SS18:SSX Reprograming
Jakob Hofvander, Alvin Qiu, Kiera Lee, Misha Bilenky, Annaïck Carles, Qi Cao, Michelle Moksa, Jonathan Steif, Edmund Su, Afroditi Sotiriou, Angela Goytain, Lesley A. Hill, Sam Singer, Irene Louise Andrulis, Jay Steven Wunder, , Martin Hirst
This study examines the epigenomic states of synovial sarcoma using multi-omics analysis, revealing a continuum of epigenomic states and identifying H3K4me3 inhibition as a potential therapeutic strategy.
bioRxiv · May 14, 2024 · PreprintCancer Biology