Author

Afroditi Sotiriou

German Cancer Research CenterORCID 0000-0002-4534-7185Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:DNA methylation· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Ana BanitoiD· 3 shared Kevin B. JonesiD· 3 shared Kyllie Smith-Fry· 2 shared Alexandros C. DimopoulosiD· 1 shared Alvin Qiu· 1 shared Andrew Stewart PoklepoviciD· 1 shared Angela GoytainiD· 1 shared Angeliki M. Stamatouli· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCancer Biology

Ana BanitoORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

BAF complex-independent gene activation by SS18::SSX

Afroditi Sotiriou, Jinxiu Li, Sanya Middha, Jake A. Ward, Selina Troester, Lianghao Mao, Martin Schneider, Dario L. Frey, Eliza C. Wray, Sara Bocedi, Kyllie Smith-Fry, Linda C. Morrison, Lara S. Carroll, Mihaly Badonyi, Joseph A. Marsh, , Ana Banito

This study shows that SS18::SSX can drive transcription independently of BAF complex interaction and relies on EP300 for gene activation, suggesting new therapeutic targets for synovial sarcoma.

bioRxiv · Jan 27, 2026 · PreprintCancer Biology

Targeting of SUMOylation leads to cBAF complex stabilization and disruption of the SS18::SSX transcriptome in Synovial Sarcoma

Konstantinos V. Floros, Carter K. Fairchild, Jinxiu Li, Kun Zhang, Jane L. Roberts, Richard Kurupi, Durga Paudel, Yanli Xing, Bin Hu, Vita Kraskauskiene, Nayyerehalsadat Hosseini, Shanwei Shen, Melissa M. Inge, Kyllie Smith-Fry, Li Li, , Anthony C. Faber

This study shows that inhibiting SUMOylation with TAK-981 stabilizes cBAF complexes and disrupts the SS18::SSX-driven transcriptome in synovial sarcoma, leading to tumor inhibition.

Nature Communications · Nov 5, 2025Peer-reviewedCancer Biology

Synovial Sarcoma Chromatin Dynamics Reveal a Continuum in SS18:SSX Reprograming

Jakob Hofvander, Alvin Qiu, Kiera Lee, Misha Bilenky, Annaïck Carles, Qi Cao, Michelle Moksa, Jonathan Steif, Edmund Su, Afroditi Sotiriou, Angela Goytain, Lesley A. Hill, Sam Singer, Irene Louise Andrulis, Jay Steven Wunder, , Martin Hirst

This study examines the epigenomic states of synovial sarcoma using multi-omics analysis, revealing a continuum of epigenomic states and identifying H3K4me3 inhibition as a potential therapeutic strategy.

bioRxiv · May 14, 2024 · PreprintCancer Biology