Interleukin-35 pretreatment attenuates lipopolysaccharide-induced heart injury by inhibition of inflammation, apoptosis and fibrosis
Huanhuan Hu, Yang Fu, Meng Li, Huasong Xia, Yue Liu, Xiaopei Sun, Yang Hu, Fulin Song, Xiaoshu Cheng, Ping Li, Yanqing Wu
This study shows that IL-35 pretreatment reduces LPS-induced heart injury by decreasing inflammation, apoptosis, and fibrosis through inhibiting NF-κBp65 and TGF-β1/Smad2/3 pathways.
International Immunopharmacology · Jul 14, 2020Peer-reviewedMolecular Biology