This paper uses a humanized mouse model and Nanopore sequencing to study metabolic responses in human liver transcriptomes, revealing novel transcripts, regulatory pathways, and dynamic RNA modifications.

bioRxiv · Jul 6, 2023 · PreprintSystems Biology

lncRNAKB: A comprehensive knowledgebase of long non-coding RNAs

Fayaz Seifuddin, Komudi Singh, Abhilash Suresh, Jennifer Judy, Yun-Ching Chen, Vijender Chaitankar, Ilker Tunc, Xiangbo Ruan, Ping Li, Yi Chen, Haiming Cao, Richard S. Lee, Fernando S. Goes, Peter P. Zandi, Mohsin Saleet Jafri, Mehdi Pirooznia

The paper introduces lncRNAKB, a comprehensive knowledgebase of 77,199 human lncRNAs with expression, conservation, and cis-eQTL data from GTEx.

Scientific Data · Oct 5, 2020Peer-reviewedBioinformatics

Interleukin-35 pretreatment attenuates lipopolysaccharide-induced heart injury by inhibition of inflammation, apoptosis and fibrosis

Huanhuan Hu, Yang Fu, Meng Li, Huasong Xia, Yue Liu, Xiaopei Sun, Yang Hu, Fulin Song, Xiaoshu Cheng, Ping Li, Yanqing Wu

This study shows that IL-35 pretreatment reduces LPS-induced heart injury by decreasing inflammation, apoptosis, and fibrosis through inhibiting NF-κBp65 and TGF-β1/Smad2/3 pathways.

International Immunopharmacology · Jul 14, 2020Peer-reviewedMolecular Biology