Antibody-mediated VWF targeting reconstitutes ADAMTS13 metalloproteinase activity and prevents thrombocytopenia in mice
Atsushi Hashimoto, Yoshiki Komeda, Fumika Kiku, Minako Oogi, Mariko Nakano, Sagano Shiina, Harue Imai, Yasuhisa Shiraishi, Kazuhiro Masuda, Atsushi Kanai
This study develops ADAMTS13 mimetics that restore VWF cleavage and prevent thrombocytopenia in iTTP mice by using antibody-mediated substrate targeting.
bioRxiv · Sep 13, 2026 · PreprintBiochemistry