Gatekeeper transcription factors regulate switch between lineage preservation and cell plasticity
T. Ray, A. Shah, G. A. Bulla, P. S. Ray
This study identifies Snai2 and Prrx1 as critical regulators of mesenchymal commitment in rat cells and shows their knockdown can reprogram cells into adipocytes, chondrocytes, osteocytes, or pluripotent stem-like cells without exogenous factors.
bioRxiv · Mar 19, 2020 · PreprintCell Biology