Oxidative stress conditions result in trapping of PHF-core tau (297-391) intermediates.
M. B. Maina, Y. Al-Hilaly, G. B. Burra, J. Rickard, C. Harrington, C. Wischik, L. Serpell
This study shows that DiY cross-linking promotes tau oligomer formation and prevents filament elongation without causing cell toxicity.
bioRxiv · Dec 7, 2020Biochemistry