Author

C. Wischik

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

C. Harrington· 2 shared Y. Al-Hilaly· 2 shared G. B. Burra· 1 shared G. Burra· 1 shared J. Rickard· 1 shared K. E. Marshall· 1 shared K. Mengham· 1 shared L. Biasetti· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBiochemistry

C. Harrington

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2 papers

Recent·Most cited

Dityrosine cross-links are present in Alzheimer's disease-derived tau oligomers and paired helical filaments (PHF) which promotes the stability of PHF-core tau (297-391) in vitro.

M. Maina, Y. Al-Hilaly, S. Oakley, G. Burra, T. Khanom, L. Biasetti, K. Mengham, K. E. Marshall, C. Harrington, C. Wischik, L. C. Serpell

This study shows dityrosine crosslinks are present in Alzheimer's disease tau oligomers and paired helical filaments, increasing their stability in vitro.

bioRxiv · May 28, 2022Biochemistry

Oxidative stress conditions result in trapping of PHF-core tau (297-391) intermediates.

M. B. Maina, Y. Al-Hilaly, G. B. Burra, J. Rickard, C. Harrington, C. Wischik, L. Serpell

This study shows that DiY cross-linking promotes tau oligomer formation and prevents filament elongation without causing cell toxicity.

bioRxiv · Dec 7, 2020Biochemistry