Trans-Lesion Synthesis and Mismatch Repair Pathway Crosstalk Defines Chemoresistance and Hypermutation Mechanisms in Glioblastoma
X. Cheng, J. An, J. Lou, Q. Gu, W. Ding, G. Droby, Y. Wang, C. Wang, Y. Gao, A. Shelton, A. B. Satterlee, B. E. Mann, Y.-C. Hsiao, C.-W. Liu, K. Liu, , Y. Yang
This study identifies RAD18's role in TMZ resistance and hypermutation in GBM by linking it to TLS and MMR pathways through CRISPR screening and mutation analysis.
bioRxiv · Oct 16, 2023 · PreprintCancer Biology