Regulation of cAMP accumulation and activity by distinct phosphodiesterase subtypes in INS-1 cells and human pancreatic β-cells
E. P. S. Pratt, K. E. Harvey, A. E. Salyer, s. Tang, G. Hockerman
This study investigates the role of PDE1, PDE3, and PDE4 in regulating cAMP levels and insulin secretion in INS-1 cells and human β-cells, finding that PDE1 inhibition enhances glucose-stimulated insulin secretion and protects against fatty acid toxicity.
bioRxiv · Mar 29, 2019Pharmacology & Toxicology