Differential Strengths Of Molecular Determinants Guide Environment Specific Mutational Fates
R. Dandage, R. Pandey, G. Jayaraj, K. Chakraborty
The paper uses Deep Mutational Scanning to analyze how environmental factors influence the fitness of single-site mutants in an antibiotic resistance gene, revealing protein stability as a key constraint.
bioRxiv · May 5, 2017Evolutionary Biology