K. Chakraborty

The PPE25 (Rv1787)-PE18 (Rv1788)-PPE26 (Rv1789) gene cluster is involved in immune evasion by Mycobacterium tuberculosis

This study identifies the PPE25-PE18-PPE26 gene cluster in Mycobacterium tuberculosis as involved in immune evasion by modulating cytokine levels and macrophage responses.

Live visualization of endoplasmic reticulum redox potential in zebrafish embryos reveals region-specific differences

This study uses transgenic zebrafish to visualize ER redox potential in live embryos, revealing region-specific deviations from expected oxidizing states.

A Novel CRISPR-Engineered, Stem Cell-Derived Cellular Vaccine

This paper describes a CRISPR-engineered cellular vaccine designed to mimic natural immunity, showing robust neutralizing antibody responses and reduced viral load in non-human primates.

Genetic editing of CISH enhances T cell effector programs independently of immune checkpoint cell surface ligand expression

This study shows that genetic editing of CISH enhances T cell anti-tumor activity independently of PD-L1 expression, outperforming PD-1 and TIGIT disruption in certain contexts.

The timing of differentiation and potency of CD8 effector function is set by RNA binding proteins

This study identifies ZFP36 and ZFP36L1 as RNA binding proteins that regulate the timing and potency of CD8+ T cell differentiation and effector function during immune response.

Copper dependent ERK1/2 phosphorylation is essential for the viability of neurons and not glia

This study shows that copper-dependent ERK1/2 phosphorylation is essential for neuronal viability but not glial cells during differentiation.

Tissue specific targeting of DNA nanodevices in a multicellular living organism

This study demonstrates the targeting of DNA nanodevices to specific cell types in C. elegans using receptor-ligand interactions and biological barriers.

Tubular lysosomes harbor active ion gradients and poise macrophages for phagocytosis

This study identifies tubular lysosomes in macrophages as having ion gradients that prepare them for phagocytosis without activating the cells.

A Novel Cell Therapy for COVID-19 and Potential Future Pandemics: Virus Induced Lymphocytes (VIL)

This paper describes a method to generate virus-specific T cells from convalescent patients using artificial antigen presenting cells and rapid expansion, showing their potential as an adoptive cell therapy for COVID-19 and other viral infections.

Distinct metabolic states of a cell guide alternate fates of mutational buffering through altered proteostasis

The paper shows that metabolic states in E. coli influence proteostasis and mutational buffering through metabolite-dependent chaperone assistance, not increased chaperone levels.

Ncl1 mediated metabolic rewiring is critical during metabolic stress

The paper shows that Ncl1 mediates metabolic rewiring in yeast under cysteine excess by linking leucine metabolism to translational control and TCA cycle function.

PI3Kδ hyper-activation promotes the development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner

This study identifies a PI3Kδ-driven B cell subset in the lungs that worsens Streptococcus pneumoniae infection independently of antibodies, and shows that inhibiting PI3Kδ improves survival.

High lumenal chloride in the lysosome is critical for lysosome function.

The paper measures lysosomal chloride levels in multiple models and finds that chloride reduction impairs lysosomal function.

Differential Strengths Of Molecular Determinants Guide Environment Specific Mutational Fates

The paper uses Deep Mutational Scanning to analyze how environmental factors influence the fitness of single-site mutants in an antibiotic resistance gene, revealing protein stability as a key constraint.