APOE ε4 allele advances the age-dependent decline of amyloid β clearance in the human cortex
A. Saito, Y. Kageyama, O. Pletnikova, G. L. Rudow, Y. An, Y. Irie, A. Kita, K. Miki, L. Li, P. Southall, K. Irie, J. C. Troncoso
This study shows that the APOE ε4 allele causes earlier age-related decline in amyloid β clearance in the human cortex, supporting early intervention strategies for Alzheimer's disease.
bioRxiv · Apr 7, 2021 · PreprintPathology