Mathematical modelling elucidates core mechanisms underpinning GnRH pulse generation
M. Voliotis, X.-F. Li, R. De Burgh, G. Lass, S. L. Lightman, K. T. O'Byrne, K. Tsaneva-Atanasova
The paper develops a mathematical model of the GnRH pulse generator, showing that increasing basal activity leads to pulsatile luteinizing hormone release and frequency changes through feedback mechanisms.
bioRxiv · Dec 11, 2018 · PreprintPhysiology