Author

K. Tsaneva-Atanasova

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Biophysics· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Organism:E. coli· 3 Approach:microscopy & imaging analysis· 3 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:fluorescence / live-cell microscopy· 2 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

M. Voliotis· 4 shared S. Pagliara· 4 shared M. Blaskovich· 2 shared U. Lapinska· 2 shared A. Campey· 1 shared A. Farbos· 1 shared A. Jeffries· 1 shared A. Smith· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersMicrobiology

M. Voliotis

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Phage-induced efflux down-regulation boosts antibiotic efficacy

S. Kraus, U. Lapinska, K. Chawla, E. Baker, E. Attrill, P. ONeill, A. Farbos, A. Jeffries, E. Galyov, S. Korbsrisate, K. Barnes, S. Harding, K. Tsaneva-Atanasova, M. Blaskovich, S. Pagliara

This study shows that phage presence reduces antibiotic efflux in bacteria, enhancing antibiotic efficacy and enabling lower concentrations for treatment.

bioRxiv · Sep 21, 2023Microbiology

Nutrient and salt depletion synergistically boosts glucose metabolism in individual bacteria

G. Glover, M. Voliotis, U. Lapinska, B. Invergo, D. Soanes, P. O'Neill, K. Moore, N. Nikolic, P. Petrov, D. Milner, S. Roy, K. Heesom, T. Richards, K. Tsaneva-Atanasova, S. Pagliara

This study shows that nutrient and salt depletion in E. coli increases glucose accumulation rates at the translational and posttranslational levels, challenging the view that growth rate alone reflects metabolic status.

bioRxiv · Jan 26, 2022 · PreprintMicrobiology

Fast bacterial growth reduces antibiotic accumulation and efficacy

U. Łapinska, M. Voliotis, K. K. Lee, A. Campey, R. Stone, W. Phetsang, B. Zhang, K. Tsaneva-Atanasova, M. Blaskovich, S. Pagliara

The paper identifies fast-growing bacterial variants that avoid antibiotic accumulation and survive treatment without genetic mutations, challenging the current understanding of antibiotic resistance mechanisms.

bioRxiv · Oct 18, 2021Microbiology

Antibiotic transport kinetics in Gram-negative bacteria revealed via single-cell uptake analysis and mathematical modelling

J. Cama, M. Voliotis, J. Metz, A. Smith, J. Iannucci, U. F. Keyser, K. Tsaneva-Atanasova, S. Pagliara

This study quantifies antibiotic uptake in E. coli using microfluidics and microscopy, showing growth phase impacts drug accumulation more than transport pathways, and develops a mathematical model to predict kinetics.

bioRxiv · Dec 6, 2019Biophysics

Mathematical modelling elucidates core mechanisms underpinning GnRH pulse generation

M. Voliotis, X.-F. Li, R. De Burgh, G. Lass, S. L. Lightman, K. T. O'Byrne, K. Tsaneva-Atanasova

The paper develops a mathematical model of the GnRH pulse generator, showing that increasing basal activity leads to pulsatile luteinizing hormone release and frequency changes through feedback mechanisms.

bioRxiv · Dec 11, 2018 · PreprintPhysiology