Histone lactylation antagonizes senescence and skeletal muscle aging via facilitating gene expression reprogramming
X. Zhang, F. Meng, W. Lyu, J. He, R. Wei, Z. Du, C. Zhang, Y. Guan, X. Huang, G. Lyu, X.-L. Tian, L. Zhang, W. Tao
This study shows histone lactylation counteracts senescence and skeletal muscle aging by reprogramming gene expression, with exercise enhancing lactylation and improving muscle function.
bioRxiv · May 26, 2023 · PreprintCell Biology