Y. Guan

The paper maps olfactory receptors to odor percepts using docking energy scores, showing a direct relationship between receptors and specific smells.

GRASP improves gene network inference using LLMs by adapting prompts to gene pairs, outperforming other strategies and recovering unannotated interactions.

This study shows that Escherichia coli lacking RecA rapidly develops beta-lactam resistance through an SOS-independent mechanism involving oxidative stress and DNA repair defects.

The paper identifies a lipid metabolism defect as a contributor to variable anemia in Diamond Blackfan anemia syndrome using a murine model and transcriptomic analysis.

The paper evaluates and optimizes sequence-based gene regulatory deep learning models using a DREAM Challenge dataset, showing improvements through architectural and training strategy refinements.

This study shows that ASO treatment rescues oligodendrocyte dysfunction in SCA3 mice by targeting mutant ATXN3, suggesting potential for glial-targeted therapies in neurodegenerative diseases.

This study uses proteomic profiling to reveal lysosomal heterogeneity and its role in longevity by identifying protein dynamics and interactions in lysosomes.

This study shows that microinfarcts in mice enhance recurrent stroke severity via NLRP3-dependent trained immunity in microglia.

The paper introduces a non-invasive neurotechnology platform with multi-modal sensors and integration into BCI2000, demonstrating its use in sleep monitoring and evoked potentials.

This study identifies LPHN2/ADGRL2 as a force-sensitive adhesion GPCR essential for normal equilibrioception by regulating mechanoelectrical transduction in utricular hair cells.

This study shows butyrate protects against SARS-CoV-2-induced tissue damage in golden hamsters by enhancing antiviral immunity and reducing oxidative stress.

This study shows histone lactylation counteracts senescence and skeletal muscle aging by reprogramming gene expression, with exercise enhancing lactylation and improving muscle function.

The paper evaluates 23 imputation models for cross-cell type epigenomic data, finding quality assessment challenging due to distributional shifts, data availability, and redundant metrics.

This study develops a bivalent vaccine using lineage-mosaic and mutation-patched spike proteins that elicit broad-spectrum antibodies and protect against multiple SARS-CoV-2 variants in hamsters.

This study evaluates an intranasal influenza-based vaccine against SARS-CoV-2 variants, showing it reduces inflammatory response and tissue damage through local immunity.

The paper benchmarks 31 subclonal reconstruction algorithms on simulated tumours, finding that algorithm choice significantly impacts performance and no single algorithm excels across all tasks.

This study shows that inducing the bacteriophage PinR in DNA repair-deficient E. coli promotes antibiotic resistance evolution by repressing antioxidative genes and causing ROS bursts.

This study identifies impaired oligodendrocyte maturation as an early feature in SCA3 disease pathogenesis through longitudinal transcriptomic analysis and functional validation in mice.

This study shows that Hoxb5 can convert multipotent blood progenitors into hematopoietic stem cell-like cells with long-term repopulating ability.

This study develops a human hepatic organoid model of ARPKD liver fibrosis, showing that the ARPKD mutation leads to fibrosis through TGFβ and PDGFRB pathways.

The paper develops a pipeline combining micro-dissection and long/short-read sequencing to identify compartment-specific isoforms in kidney tissue, finding distinct isoform expression in glomerular and tubulo-interstitial compartments.

The paper reports the discovery of a neutralizing nanobody, VHH60, effective against SARS-CoV-2 and its variants, with high potency and protective efficacy in mice.

The paper develops predictive models for preterm birth using maternal blood multi-omics data, finding transcriptomic and proteomic markers can predict gestational age and spontaneous preterm birth with high accuracy.

The paper compares rule-based and data-driven molecular representations for predicting drug combination effects using standardized screening data from 112 cancer cell lines.

Leopard predicts TF-binding sites at single-nucleotide resolution with high accuracy and speed, outperforming existing methods.

The paper evaluates digital biomarkers from wearable data to predict Parkinson's disease status and symptom severity using a crowdsourced challenge.

The paper identifies ATF3 as a key driver of chromatin accessibility remodeling during senescence, linking it to the regulation of senescence programs.

This paper develops a subunit vaccine against SARS-CoV-2 that induces sterilizing immunity in hamsters, with high neutralizing antibody titers and protection against infection and symptoms.

This study shows that reduced IF1 in obesity leads to mitochondrial reprogramming through ANT2 downregulation, improving insulin sensitivity despite increased body weight on a high-fat diet.

This study shows that inactivating ATPIF1 enhances CD8+ T cell antitumor activity by reprogramming their metabolism, leading to better tumor suppression in mouse models.