AlphaGEM Enables Precise Genome-Scale Metabolic Modelling by Integrating Protein Structure Alignment with deep-learning-based Dark Metabolism Mining
Weishang Han, Luchi Xiao, Haocheng Sun, G. M. Xiang, Qianxi Jia, Haoyu Wang, Boyang Ji, Cheng Zhang, Eduard Johannes Kerkhoven, Jens Nielsen, Hongzhong Lu
AlphaGEM constructs genome-scale metabolic models using structural alignment and deep learning, improving accuracy over existing methods for diverse species.
Nature Communications · Jul 16, 2026Peer-reviewedBioinformatics