Haoyu Wang

AlphaGEM Enables Precise Genome-Scale Metabolic Modelling by Integrating Protein Structure Alignment with deep-learning-based Dark Metabolism Mining

AlphaGEM constructs genome-scale metabolic models using structural alignment and deep learning, improving accuracy over existing methods for diverse species.

Efficient Cell Factory Design by Combining Meta-Heuristic Algorithm with Enzyme Constrained Metabolic Models

MetaStrain combines enzyme-constrained models with meta-heuristic algorithms to efficiently identify combinatorial gene targets for improving microbial product yields.

Creating an energy efficient central metabolism for boosting biosynthesis without compromising cell growth of yeast

This paper engineers an energy-efficient pentose phosphate pathway in yeast to boost fatty acid production without compromising cell growth, achieving a record 41.7 g/L titer.

StrainOptimizer empowers rational cell factory design through multi-scale metabolic models with expression and proteome constraints

StrainOptimizer improves microbial cell factory design by integrating multi-scale metabolic models with expression and proteome constraints, achieving higher bioproduction in yeast.

Yeast adapts to diverse ecological niches driven by genomics and metabolic reprogramming

This study characterizes the genomic and metabolic adaptations of Saccharomyces cerevisiae across diverse niches using pan-genome and metabolic modeling.