Microbiome Modulation Uncouples Efficacy and Toxicity Induced by Programmed Death-1/Programmed Death-Ligand1 Blockade
L. L. Cogrossi, P. Zordan, M. Grioni, A. Tosi, N. Rizzo, A. Policastro, B. Mattorre, M. Lorenzoni, G. Meregalli, S. Sisti, F. Sanvito, M. Chesi, L. Bergsagel, N. Clementi, A. Rosato, M. Bellone
This study shows that administering Prevotella melaninogenica to mice with multiple myeloma delays disease progression and enhances the efficacy of PD-1/PD-L1 blockade while reducing toxicity.
bioRxiv · May 8, 2024 · PreprintImmunology