DNA-encoded library (DEL)-enabled discovery of proximity-inducing small molecules
J. W. Mason, L. Hudson, M. V. Westphal, A. Tutter, G. Michaud, W. Shu, X. Ma, C. W. Coley, P. A. Clemons, S. Bonazzi, F. Berst, F. J. Zecri, K. Briner, S. L. Schreiber
This paper uses DNA-encoded libraries to discover small molecules that induce protein-protein associations between BRD4 and VHL-elongin C-elongin B.
bioRxiv · Oct 13, 2022Pharmacology & Toxicology