W. Shu

A small molecule VHL molecular glue degrader for cysteine dioxygenase 1

The paper identifies a small molecule that acts as a molecular glue degrader for CDO1 by recruiting it into the VHL E3 ligase complex, leading to its degradation.

Exogenous myristate fuels the growth of symbiotic arbuscular mycorrhizal fungi but disrupts their carbon-phosphorus exchange with host plants

This study shows that exogenous myristate supports AMF growth but reduces phosphorus transfer to host plants, suggesting it may hinder symbiosis.

Hydrophobic bulk conservation and genetic code determine the pattern of prokaryotic genome organization

The paper analyzes prokaryotic genome organization patterns and finds that GC-content, mutational biases, and genetic code influence GC-skew, AT-skew, and gene strand bias through synonymous and nonsynonymous substitutions.

A multiscale theory for spreading and migration of adhesion-reinforced mesenchymal cells

The paper develops a multiscale theory to explain how mesenchymal cells spread and migrate on substrates with varying stiffness and viscosity, incorporating adhesion reinforcement mechanisms.

Crystal structure of mRNA cap (guanine-N7) methyltransferase E12 subunit from monkeypox virus and discovery of its inhibitors

The paper reports the crystal structure of MPXV E12 and identifies potential inhibitors through docking studies.

Metagenomic discovery of Candidatus Parvarchaeales related lineages sheds light on the adaptation and diversification from neutral-thermal to acidic-mesothermal environments

This paper identifies new Parvarchaeales lineages through metagenomics and reveals their adaptation strategies to extreme environments via genomic and metabolic analysis.

Stratified tissue biofabrication by rotational internal flow layer engineering

This paper introduces RIFLE, a biofabrication method that creates multi-layered tissue-like structures with microscale cell-width layers, demonstrating its ability to encapsulate high-density cells in collagen.

DNA-encoded library (DEL)-enabled discovery of proximity-inducing small molecules

This paper uses DNA-encoded libraries to discover small molecules that induce protein-protein associations between BRD4 and VHL-elongin C-elongin B.

MAM-STAT3-induced upregulation of mitochondrial Ca+2 causes immunosenescence in patients with type A mandibuloacral dysplasia

This study identifies mitochondrial Ca+2 dysregulation via MAM-STAT3 as a driver of immunosenescence in type A mandibuloacral dysplasia.

Genomic legacies of ancient adaptation illuminate the GC-content evolution in bacterial genomes

This study shows that genomic GC content variation in bacteria is influenced by ancient adaptation legacies, particularly through DNA replication and repair systems, rather than neutral processes.

A multiscale whole-cell theory for mechano-sensitive migration on viscoelastic substrates

This paper develops a multiscale whole-cell theory to model mesenchymal cell migration on viscoelastic substrates, showing how mechanical and chemical cues influence migration behaviors like durotaxis and anti-durotaxis.

A Refined View of Airway Microbiome in Chronic Obstructive Pulmonary Disease at Species and Strain-levels

The paper analyzes the airway microbiome in COPD patients at species and strain levels, revealing intra-genus diversity linked to inflammatory phenotypes and clinical outcomes.

The Structural Basis of Indisulam-Mediated Recruitment of RBM39 to the DCAF15-DDB1-DDA1 E3 Ligase Complex

This study determines the structure of the DCAF15-DDB1-DDA1-Indisulam-RBM39 complex, revealing how Indisulam promotes RBM39 degradation via a novel degron motif.