Glucocerebrosidase reduces the spread of protein aggregation in a Drosophila melanogaster model of neurodegeneration by regulating proteins trafficked by extracellular vesicles
K. A. Jewett, R. E. Thomas, C. Q. Phan, G. Milstein, S. Yu, L. J. Pallanck, M. Y. Davis
This study shows that restoring glucocerebrosidase in muscle tissue reduces protein aggregation in both muscle and brain in a Drosophila model of Parkinson's disease by regulating extracellular vesicle content.
bioRxiv · May 15, 2020Cell Biology