Modulation of neuronal resilience during aging by Hsp70/Hsp90/STI1 chaperone system
R. Lackie, A. Razzaq, S. M. K. Farhan, G. Moshitzky, F. H. Beraldo, M. H. Lopes, A. Maciejewski, R. Gros, J. Fan, W.-Y. Choy, D. Greenberg, V. R. Martins, M. Duennwald, H. Soreq, V. F. Prado, M. A. M. Prado
This study investigates the role of STI1 in the Hsp70/Hsp90 chaperone system during aging, showing that STI1 loss leads to neurodegeneration and memory deficits in mice.
bioRxiv · Feb 13, 2019 · PreprintCell Biology